CASP2 and lung cancer: In an unbiased experimental approach, aimed at detecting caspase-2 protein interactions, which could serve as further elucidation of molecular mechanisms that have been assigned to the enzyme, we performed a Y2H assay using a full-length caspase-2 wild-type construct as bait to screen a randomly primed human lung cancer cell line (A549, H1703, H460) cDNA library (83 million clones, 8-fold the complexity of the library).