Finally, it was observed that the caspase-2-RFXANK interaction occurred in the cytoplasmic compartment, as verified by co-IP of endogenous caspase-2 using a specific RFXANK antibody and fractionated acute myeloid leukemia OCI-AML2 cell lysates (Fig. 2d). The gene discussed is RFXANK; the disease is acute myeloid leukemia.