PAK2 and hepatocellular carcinoma: Moreover, miR-138 reportedly induced cell cycle arrest by targeting CCND3 in hepatocellular carcinoma cells37 and miR-592 inhibited cell proliferation by suppressing CCND3 expression in CRC38 Similarly, miR-4779 efficiently induced cell cycle arrest and apoptosis by targeting CCND3, and further contributed to cell cycle arrest by suppressing PAK2 expression.