Moreover, miR-138 reportedly induced cell cycle arrest by targeting CCND3 in hepatocellular carcinoma cells37 and miR-592 inhibited cell proliferation by suppressing CCND3 expression in CRC38 Similarly, miR-4779 efficiently induced cell cycle arrest and apoptosis by targeting CCND3, and further contributed to cell cycle arrest by suppressing PAK2 expression. This evidence concerns the gene CCND3 and hepatocellular carcinoma.