In an effort to test the correlation between MGMT hypermethylation rate and different staging of NSCLC, we observed that MGMT hypermethylation rate was higher in NSCLC patients with advanced stage than in early stage (OR = 0.77, 95% CI = 0.59~0.99, p = 0.04, Fig. 2B). This evidence concerns the gene MGMT and non-small cell lung carcinoma.