Under normoxic and hypoxic conditions, the two H5CmTERT promoter-driven oncolytic adenoviruses (H5CmTERT-Ad and H5CmTERT-Ad/TRAIL) elicited highly cancer-specific and more potent glioblastoma cell-killing effect than Rb7Δ19 did, which expresses an adenovirus gene under control of the endogenous adenovirus promoter (Fig. 2). Here, TNFSF10 is linked to glioblastoma.