TNFSF10 and glioblastoma: Moreover, H5CmTERT-Ad/TRAIL-mediated induction of apoptosis was significantly enhanced under hypoxic conditions (normoxia vs. hypoxia; 70.8 ± 11.4% vs. 98.0 ± 2.8% for U87MG glioblastoma cells, 31.8 ± 8.4% vs. 96.4 ± 3.5% for U251N glioblastoma cells; P < 0.05 or P < 0.001).