It should be noted that H5CmTERT-Ad-treated tumour tissues showed a 73.4% smaller tumour region than did those treated with H5CmTERT-Ad (P < 0.05), indicating that stTRAIL expression by H5CmTERT-Ad/TRAIL can enhance the anti-tumour effect of the oncolytic adenovirus against orthotopic glioblastoma. The gene discussed is TNFSF10; the disease is neoplasm.