Of note, H5CmTERT-Ad and H5CmTERT-Ad/TRAIL were not cytotoxic toward normal cells (10- or 2-fold higher MOI was used for BJ and SVG-P12 than the highest dose used to treat glioblastoma cells, respectively), thus demonstrating good cancer specificity of the H5CmTERT-based oncolytic adenoviruses. Here, TNFSF10 is linked to cancer.