Moreover, H5CmTERT-Ad/TRAIL-treated tumours showed significantly greater quantity of viral progenies spread over larger areas than did those treated with H5CmTERT-Ad (P < 0.001), suggesting that stTRAIL-induced apoptosis may facilitate secondary infection of neighbouring tumour cells and enhance the viral distribution of the oncolytic adenovirus in tumour tissue. The gene discussed is TNFSF10; the disease is infection.