TNFSF10 and neoplasm: Furthermore, H5CmTERT-Ad/TRAIL-treated tumours showed abundant stTRAIL expression, which led to stronger induction of apoptosis as compared with H5CmTERT-Ad (P < 0.01 versus H5CmTERT-Ad), indicating that oncolytic-adenovirus-mediated expression of stTRAIL can enhance anti-tumour efficacy of an adenovirus by promoting apoptotic cell death (Fig. 6a and b).