This potent anti-cancer effect of the H5CmTERT promoter-driven oncolytic adenovirus is further enhanced by expression of stTRAIL, which greatly enhances induction of apoptosis and viral distribution in both subcutaneous and orthotopic xenograft models of glioblastoma that are resistant to TRAIL-mediated apoptosis. This evidence concerns the gene TNFSF10 and glioblastoma.