Moreover, 10 loci contain genes linked to diseases, including 4 of the newly identified loci; namely, NUP188 has a role in heterotaxy23, SEMA4B in hypoxia and lung cancer24, CCBL2 in neurodegenerative diseases, and TMPRSS11E in squamous cell carcinomas25. This evidence concerns the gene NUP188 and neurodegenerative disease.