BCL2 and viral infectious disease: In contrast to the attenuated replication in Bcl-2 knockdown PC3 cells (Fig. 2d), neither rapamycin nor chloroquine had significant effects on viral infection, E1A expression or replication in combination with mitoxantrone (Supplementary Fig. 4C−E) and consequently, the desensitisation and sensitisation were not due to changes in viral propagation but rather direct effects on cellular factors.