However, based on the decreased LC3II/I ratios in response to viral E1A12S expression, the attenuation of autophagy by Ad∆∆ is likely to occur at an early stage in prostate cancer cells, prior to autophagosome formation in line with the identification of Bcl-2 inhibition of autophagy as an essential requirement for the synergistic cell killing. Here, BCL2 is linked to Familial prostate cancer.