FOS and acute lymphoblastic leukemia: C. albicans mutants (R61A, R93A, R61A + R93A, and ALL KA) harboring replacements of Arg61 and Arg93 with alanine within Ece1p, which directly flank candidalysin (see Fig. S2 in the supplemental material), were unable to induce epithelial damage, c-Fos production, DNA binding, MKP1 phosphorylation, and cytokine secretion in vitro (Fig. 1), which are key readouts of candidalysin activity (3).