In addition, VEGF and IGF-1 receptor genetic variations may modify the inverse association between gestational hypertension (a symptom of preeclampsia) and mammographic density [42], and IGF1R genetic variations may predict breast cancer risk in patients with preeclampsia [33], further supporting the role of genetic factors in the association between preeclampsia and breast cancer, and suggesting future studies on these potential genetic factors are needed. This evidence concerns the gene VEGFA and breast cancer.