Tumor samples showed activating mutations in EZR-ROS1, as well as the concomitant alterations NQO1(P187S), TYMS (− 6 bp non-frame shift deletion), UGT1A1(G71R), XRCC1(Q339R), CYP2D6(P34S), DPYD (I543V), and MTHFR (A222V). This evidence concerns the gene ROS1 and neoplasm.