In gliomas, miR-93-5p mediated phosphoinositide 3-kinase (PI3K)/Akt signaling activation by directly suppresses PI3K/Tensin homology protein (PTEN), pleckstrin homology domain, and leucine-rich repeat protein phosphatase 2 (PHLPP2) and forkhead box o3 (FOXO3) expression that results in the promotion of cell proliferation [46]. This evidence concerns the gene FOXO3 and central nervous system cancer.