HIF1A and clear cell renal carcinoma: Interestingly, stabilization of hypoxia-inducible factor 1 alpha (HIF1α) was associated with downregulation of PGC1α TFAM mRNA and protein levels in likewise chemoresistant Von Hippel-Lindau tumor suppressor protein (VHL)-deficient clear-cell renal carcinoma tumors and cell lines [29].