COL1A2 and hypopharynx cancer: In patients with hypopharyngeal cancers, methylation of COL1A2 and VEGFR1 promoters correlated positively with recurrence (odds ratio (OR) = 3.19, 95% CI: 1.33–7.66, p = 0.009 and OR = 3.07, 95% CI: 1.25–7.49, p = 0.014, respectively) (Figure 3A).