SAMHD1 and HIV-1 infection: HIV-1 production is reduced and viral export is impaired in cells where the endosomal sorting complex for transport II protein EAP45 has been ablated [118], whereas knockout of the SAMHD1 gene, encoding the deoxynucleoside triphosphate triphosphohydrolase SAM domain- and HD domain containing protein 1 (a), increased HIV-1 infection [110].