As several classes of antihypertensive drugs such as angiotensin-converting enzyme (ACE) inhibitors [61,142,143,144,145,146], angiotensin II type 1 receptor blockers [144,145,147], angiotensin II receptor–neprilysin inhibitor [147], and diuretics [143] were effective in improving reduced EDH-mediated responses associated with hypertension, blood pressure lowering per se appears to play a crucial role in these improvements. This evidence concerns the gene ACE and hypertensive disorder.