AKT1 and colonic neoplasm: The previous study demonstrated that aloperine induced a G2/M-phase cell cycle arrest, and inhibited Janus kinase (JAK)/Signal transducer and activator of transcription 3 (Stat3), phosphatidylinositol 3-kinase/Akt, as well as Bcl-2, in a human colon cancer cell line [2].