Although CTNNB1 mutation is more significant in hepatitis C virus (HCV)-related HCC and aflatoxin B1-related HCC as compared to hepatitis B virus (HBV)-related HCC [41,43,46], a recent study revealed that genetic polymorphisms in CTNNB1 and AXIN1 are correlated to HBV-related HCC development and patients’ survival outcomes [47]. Here, AXIN1 is linked to hepatocellular carcinoma.