RUNX2 and chondrosarcoma: Notably, SOX4 and runt related transcription factor 2 (RUNX2), which are both implicated in regulation of chondrogenesis and osteogenesis, are targets of miR-30a, which is progressively downregulated with increasing chondrosarcoma grade, leading to a relative overexpression of SOX4 and RUNX2 [40].