A single nucleotide polymorphism (SNP) frequently found in the promoter region of MMP-1 in human chondrosarcoma tissues and established chondrosarcoma cell lines [99] generates an artificial avian erythroblastosis virus E26 oncogene homolog (ETS) binding site, which has been implicated in enhanced MMP-1 expression in several carcinomas [100]. The gene discussed is MMP1; the disease is carcinoma.