The purpose of the present research was to design and synthesize novel porphyrin derivatives with methyl pyrazole and 3,4-BCP as a meso-subtituent, as well as their in silico study to obtain information on their interaction with CAIX and nuclear receptor REV-ERBβ which are associated with the cancer cells, and their cytotoxic effect on cancer cell lines. The gene discussed is NR1D2; the disease is cancer.