Interestingly, reovirus is among the pathogens that preferentially activate IFN-λ production instead of type I IFN upon infection, signaling via retinoic acid-inducible gene I (RIG-I)-like receptors (RLR) and peroxisome-associated mitochondrial antiviral-signaling protein (MAVS) to activate type III IFN expression [65]. Here, RIGI is linked to infection.