APC and cervical squamous intraepithelial neoplasia: CMS2 (canonical, 37%) is characterized as exhibiting MSS, chromosomal instability (CIN), and WNT/MYC pathway activation; having a CIMP-negative and SCNA-high phenotype; showing the presence of APC and TP53 mutations; occurring in the distal colon to the rectum; and showing superior survival after a relapse.