HNF4A and colorectal carcinoma: The genomic and proteomic approach revealed the importance of chromosome 20q amplification, including HNF4A, TOMM34, and SRC. Although HNF4A is a transcription factor that plays a key role in normal gastrointestinal development, there are contradictory studies regarding whether HNF4A acts as an oncogene or a tumor suppressor gene in CRC [31].