LLGL1 and cancer: As the human orthologs of Lgl, HUGL1 and/or HUGL2, are reported to be downregulated in breast and other epithelial cancers, we turned to the genetically tractable model Drosophila to explore the effects of lgl loss on the miRNA transcriptome and to identify miRNAs that may act as effectors of lgl's ability to protect against cancer progression by modulating pathways involved in tumorigenesis including cell polarity, proliferation, differentiation, adhesion, cell fate and stem cell expansion.