Although at this point we do not know whether Lgl regulates the processing of these miRNAs directly or indirectly, via RNA binding proteins such as FMRP or AGO1, our data indicate that loss of lgl leads to the dysregulation of specific miRNAs in a temporal manner that corresponds to critical stages of tumor progression including initiation, growth and malignant progression. Here, AGO1 is linked to neoplasm.