Our observations that cell differentiation of CTBs into iEVTs during placental development correlates with precise upregulation of PLAC8 protein level and previous findings that mouse PLAC8 regulates the differentiation of acute myeloid leukemia cells (Wu et al., 2010) naturally made us wonder whether this newly gathered PLAC8 might contribute to the CTBs differentiation process. Here, PLAC8 is linked to acute myeloid leukemia.