PLAC8 and acute myeloid leukemia: Subsequently, PLAC8 has been found to play important roles during cell apoptosis and proliferation as a c-Myc-repressed target (Mourtada-Maarabouni et al., 2013; Rogulski et al., 2005), and during the differentiation of acute myeloid leukemia cells (Wu et al., 2010).