FGF10 and LADD syndrome: In humans, disruption of FGF10-FGFR2IIIb signaling causes a range of complex developmental disorders including cleft lip/palate (Rice et al., 2004), autosomal dominant aplasia of lacrimal and salivary glands (ALSG) (Entesarian et al., 2005) and lacrimo-auriculo-dento-digital (LADD) syndrome (Milunsky et al., 2006; Riley et al., 2007).