Classical HGPS is caused by a de novo heterozygous mutation (1824C>T, p.G608G) in exon 11 of LMNA (De Sandre-Giovannoli et al., 2003), which activates a cryptic splice site resulting in the expression of a mutant lamin A, termed progerin (Eriksson et al., 2003). Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.