From this approach, two proteins were identified – the protein phosphatase 2A regulatory subunit PsrA (Lee et al., 2008), associated with cancer onset (Kiely and Kiely, 2015), and the presenilin 1 orthologue PsenB (Ludtmann et al., 2014), implicated in AD (De Strooper and Annaert, 2010) – which partially control the effects of these compounds. Here, PSEN1 is linked to Alzheimer disease.