CD86 and multiple sclerosis: Higher CD86 expression in this B cell subset has previously been associated with multiple sclerosis versus controls (Niino et al., 2009; Fraussen et al., 2016) with relapse versus remission in multiple sclerosis (Niino et al., 2009), and with a phenotype of high neurodegeneration in multiple sclerosis (Comabella et al., 2016).