Some of these genes have been previously implicated inautoimmune disease: PADI2 expression has been demonstrated to correlatewith arthritis severity in mice (Johnsen etal., 2011), LGALS1 damages cartilage via inflammationin osteoarthritis (Toegel et al.,2016) and PLCL2 has been associated with systemic sclerosis(Arismendi et al.,2015). This evidence concerns the gene LGALS1 and arthritic joint disease.