Aspirin and P2Y12 inhibitors widely used to prevent platelet aggregation in patients with coronary artery disease has limited efficacies compared to warfarin for the prevention of ischemic stroke in patients with AF [26, 27] and therapeutic anticoagulation with warfarin has been the standard of care for AF patients to prevent ischemic stroke events. Here, P2RY12 is linked to atrial fibrillation.