In the OIR model, characterized by hypoxia-induced pathological pre-retinal neovascularization, the B2R blockade reduced retinal neovessels, as determined by the area of retinal tufts (unorganized, small-caliber vessels, also termed pathological neovessels), and the expression of VEGF and FGF-2 in pathological retinal vessels, suggesting that drugs targeting B2R signaling might have a role in proliferative retinal diseases. The gene discussed is FGF2; the disease is Abnormal retinal morphology.