The protective effects of MMO in NAFLD mice are associated with its ability to regulate the NF-κB anti-inflammation signaling pathways to inhibit inflammation; regulate AMPK-α, PPAR-α, and SREBP-1c to improve lipid metabolism disorder; and regulate Bcl-2/Bax anti-apoptosis signaling pathways to prevent liver cell apoptosis. Here, NFKB1 is linked to metabolic dysfunction-associated steatotic liver disease.