To investigate the effect of MAD2L2 on CRC development, we knocked down MAD2L2 with its specific shRNA in HCT116 and SW480 cells and found that MAD2L2 knockdown promoted the proliferation of CRC cells and western blots showed that the level of NCOA3 was elevated when MAD2L2 was down‐regulated (Fig. 2A,C). Here, MAD2L2 is linked to colorectal carcinoma.