Considering that chromosome instability is the major cause of CRC (Pino and Chung, 2010), and the expression of MAD2L2 was higher in CRC cells and tissues (Fig. 1C, Table 1), we presumed that MAD2L2 had elevated expression in response to DNA damages to serve as a protective factor in CRC. This evidence concerns the gene MAD2L2 and colorectal carcinoma.