Our data demonstrated that knockdown of MAD2L2 increased NCOA3 expression and enhanced the proliferation, colony formation, and migration of CRC cells, whereas overexpression of MAD2L2 had the opposite effects, which were reversed by NCOA3 overexpression (Fig. 2,3 and 6A‐D). The gene discussed is MAD2L2; the disease is colorectal carcinoma.