Given that CRC cells have increased DNA damage and chromosome instability (Guo et al., 2016; Ribeiro et al., 2008; Xia et al., 2016), and MAD2L2 plays a critical role in DNA repair, we proposed that the expression of MAD2L2 was elevated in CRC tissues as a stress response, and this was supported by our result that MMS and cisplatin treatment induced MAD2L2 expression (Fig. 5E,F). This evidence concerns the gene MAD2L2 and colorectal carcinoma.