Immunohistochemical (IHC) analysis revealed that both proteins had significantly higher expression in CRC tissues than in adjacent normal tissues (ANT) (P < 0.001, Table 1), and the patients with high MAD2L2 expression tend to have a low level of NCOA3 (Fig. 1D case 1), while the patients with low MAD2L2 expression tend to have a high level of NCOA3 (Fig. 1D case 2), and the Spearman rank correlation analysis showed that MAD2L2 was in inverse correlation with NCOA3 (rs = −0.238, P = 0.017) (Fig. 1E). Here, MAD2L2 is linked to colorectal carcinoma.