Moreover, mutations of a group of specific tumor suppressor genes and oncogenes, such as KRAS, PIK3CA, APC, TP53, and so forth, are found to accumulate in CRCs with the typical karyotypic abnormalities caused by CIN (Colussi et al., 2013), though it remains unclear whether these mutations initiate CIN or vice versa. The gene discussed is TP53; the disease is cervical squamous intraepithelial neoplasia.