Accumulating evidence shows that NCOA3 is highly expressed in a various human cancers (Anzick et al., 1997; Xu et al., 2010; Zhou et al., 2005), and it can interact with nuclear receptors and other transcription factors to regulate the expression of their target genes involved in many signaling pathways, including EGFR, Akt, MAPK, E2F1, and Notch (Long et al., 2012; Louie et al., 2004; Mo et al., 2015; Yan et al., 2006). This evidence concerns the gene E2F1 and cancer.