Based on prior reports that GSCs are the most aggressive cellular population responsible for glioblastoma recurrence (Bao et al., 2006; Rich, 2016) and the role of numerous KDMs in stem cell maintenance (Amente et al., 2013; Andricovich et al., 2016; He et al., 2011, 2013), we hypothesized specific function of KDM2B in GSCs. Here, KDM2B is linked to glioblastoma.