Several histone demethylases, including LSD1, KDM5A, and KDM5B, are upregulated in malignant gliomas, sustaining cell growth, and resistance to chemotherapy (Amente et al., 2015; Banelli et al., 2015; Black et al., 2013; Dai et al., 2014; Hayami et al., 2011; Tzatsos et al., 2013). Here, KDM5B is linked to malignant glioma.