YTHDC2 and malignant colon neoplasm: It has also been proposed that YTHDC2 promotes mRNA translation, based on effects of shRNA knockdown of YTHDC2 in human colon cancer cell lines (Tanabe et al., 2016), as well as measures of apparent translation efficiency of putative YTHDC2 targets in mouse testis and of artificial reporter constructs in HeLa cells (Hsu et al., 2017).