In summary, our study showed that TLR4 protein expression level in melanoma cells wassignificantly higher than that in normal skin cells, TP could decrease TLR4 proteinexpression levels in normal and activated (LPS) melanomas, TLR4 could enhance theproliferating, migrating and invading ability of melanoma cells and 67LR blockingcould abolish the suppressions of TP on melanomas. This evidence concerns the gene TLR4 and melanoma.