TLR4 and melanoma: According towestern blot, TP and TLR4 siRNA down-regulated TLPR4 expression andTP+67LR-shRNA up-regulated TLR expression (P <0.05, Figure 4(a)).Furthermore, in TP/TLR4 siRNA groups, the proliferation of melanomas wereremarkably weaker (P < 0.05, Figure 4(b)), themigration of melanomas were significantly lower (P< 0.05, Figure 4(c)and (d)), and theinvasive melanoma cells were prominently decreased, all compared with group ofMock (P < 0.05, Figure 4(e)).