Toll-like receptors (TLRs) are recognized as pattern recognition receptor proteinswhich help defend the invading pathogens.11 The study has demonstrated that TLRs are expressed in keratinocytes andmelanocytes, the main part of the skin and arising-expression in skin cancers.12 Toll-like receptor 4 (TLR4) is a member of the TLRs family and has beenwidely studied for its ability to fight many diseases.13 In TLRs family, TLR4 is frequently studied for its ability to fight manydiseases. The gene discussed is TLR4; the disease is skin cancer.