An important property of the neurodegenerative diseases is the downregulated oxidative phosphorylation because of the dysfunctional brain mitochondria and the varied genes including UQCRC1, UQCR10, SDHB, ATP5B, ATP5C1, NFUFA1, and VDAC1. Here, UQCR10 is linked to neurodegenerative disease.