Within the hematopoietic compartment, MTG16 appears to take a front-seat role, as MTG8 is expressed to a significant degree only in differentiated erythroid cells and several leukemia cell lines (HL60, Kasumi-1, and HEL), while MTGR1 is constitutively expressed at relatively low levels in all hematopoietic cells and is therefore not believed to be serving a major, regulatory role. This evidence concerns the gene CBFA2T3 and leukemia.