CBFA2T2 and Familial adenomatous polyposis: A recent study in the Apc1638/+ mouse model, which replicates familial adenomatous polyposis (FAP) and features intestinal epithelium prone to Wnt dysregulation and colorectal polyps/carcinoma, showed that deletion of Mtgr1, but not Mtg16, increased tumor multiplicity tenfold.