The current state of the literature concerning IL-6 and cognitive decline in prospective cohorts of old adults has so far produced mixed findings (Weaver et al., 2002; Yaffe et al., 2003; Dik et al., 2005; Jordanova et al., 2007; Rafnsson et al., 2007; Schram et al., 2007; Singh-Manoux et al., 2014), with some stating a significant association between baseline IL-6 with cognitive decline while others failed to replicate such results. Here, IL6 is linked to Mental deterioration.