We also provide evidence that, oppositely to the 3xTg-AD mice, the PERK/eIF2α axis within the unfolding protein response (UPR) is attenuated in the PDK1K465E/K465E neurons and brain samples in an age-dependent manner, which confers cellular resistance against endoplasmic reticulum (ER) stressors such as tunicamycin. This evidence concerns the gene EIF2A and Alzheimer disease.