KCNJ10 and juvenile myoclonic epilepsy: In addition, genetic association of the KCNJ10 gene polymorphism or down-regulation of the Kir4.1 expression was observed in idiopathic generalized epilepsy patients (Phani et al., 2014; Guo et al., 2015) and TLE patients (Das et al., 2012; Heuser et al., 2012; Steinhäuser et al., 2012), respectively.