To investigate the molecular mechanisms of protection against angiotensin II-induced cardiac hypertrophy by anti-IL-22 nAb, the expression of IL-22/IL-22R1, the activation of the STAT3, ERK, JNK, and P38 pathways, and the mRNA levels of prohypertrophic inflammatory cytokines in LV were evaluated. This evidence concerns the gene AGT and cardiac hypertrophy.