MAPK8 and cardiac hypertrophy: To investigate the molecular mechanisms of protection against angiotensin II-induced cardiac hypertrophy by anti-IL-22 nAb, the expression of IL-22/IL-22R1, the activation of the STAT3, ERK, JNK, and P38 pathways, and the mRNA levels of prohypertrophic inflammatory cytokines in LV were evaluated.