To investigate the possible role of Mfn2 in sepsis-induced T cell apoptosis, we constructed an overexpression lentiviral vector encoding either Mfn2 (LV-Mfn2) or LV-mCherry (as a scrambled control virus) and a silencing lentiviral vector expressing sh-Mfn2 (LV-Mfn2 RNAi) or LV-RFP (as a scrambled control virus). The gene discussed is MFN2; the disease is Sepsis.