We demonstrate differential responses of U87 and U373 GBM cells to MSC in terms of cell proliferation, cell cycle and GBM/MSC cell-cell interaction (vesicle transfer, fusion events and entosis), B1R agonist des-Arg9-BK stimulation of U87/BM-MSC mixed spheroids and increased migration/invasion of U87 cells. Here, BDKRB1 is linked to glioblastoma.