However, ML5 radiolabeled with N-succinimidyl 4-18F-fluorobenzoate (18F-SFB), 18F-FB-ML5, exhibited an ~100-fold loss of affinity for MMP-12 compared to the parent compound (IC50 = 138.0 nM and 31.5 nM for MMP-12 and MMP-9, respectively14), which led to fairly diminished performance in in vivo experiments using tumor bearing mice14 and short-term CS exposed mice15. This evidence concerns the gene MMP12 and neoplasm.