As expected, our results showed that the increased Snail1 expression in SMMC7721-DPYD-OE cells, which had high DPYD expression, could markedly be reversed by p65-inhibitor BAY11-7082, indicating that the activity of Snail1 was regulated by p65 phosphorylation in HCC cells (Fig. 8b). Here, DPYD is linked to hepatocellular carcinoma.