DPYD and hepatocellular carcinoma: DPYD expression in HCCLM3, a DPYDhigh HCC cell line, was successfully downregulated (HCCLM3-shDPYD), and in SMMC7721, a DPYDlow HCC cell line, was stably upregulated (SMMC7721-DPYD-OE), compared with their parental cell lines (Figs. 4a–d).