BCL2 and osteosarcoma: HeLa cervical carcinoma, MDA-MB-231 breast adenocarcinoma, Saos-2 osteosarcoma, and Panc-1 pancreas ductal carcinoma cells all displayed statistically significant reductions in TAF6δ-dependent apoptosis when the mitochondrial pathway was blocked via overexpression of anti-apoptotic Bcl-2 proteins (Supplementary Fig. 2).