This BLC10 phosphorylation, marked by the appearance of a P/I induced slower migrating BCL10 isoform, is distinctively reduced in P/I stimulated Jurkat T-ALL cells pre-treated with SB21 (Fig. 5A) suggesting that GSK3β might modulate CBM complex formation by regulating BCL10 phosphorylation. Here, BCL10 is linked to acute lymphoblastic leukemia.