For this, Jurkat T-ALL cells were either left untreated or were pre-treated with SB21 or SB415286 (SB41) prior to P/I stimulation and the resulting whole cell extracts were subjected to BLC10 immunoprecipitation coupled to anti-CARMA1 immunoblot analyses (Fig. 2A). Here, CARD11 is linked to acute lymphoblastic leukemia.