To further dissect the relationship of GSK3β and IKK2 as BCL10 kinases an in vivo phosphorylation experiment was performed using either Jurkat-shControl cells or a Jurkat T-ALL cell line with a stable shRNA-mediated IKK2 knock down (IKK2-shRNA). The gene discussed is IKBKB; the disease is acute lymphoblastic leukemia.