This analysis showed enrichment of genes expressed in pancreas (ranked first in tissue enrichment analysis, p = 7.8 × 10−4, FDR < 0.05, Supplementary Data 2) and cellular response to insulin stimulus (ranked second in gene-set enrichment analysis, p = 3.9 × 10−8, FDR = 0.05, Supplementary Data 3, Supplementary Fig. 2, Supplementary Fig. 3), in concordance with the current knowledge of the molecular basis of T2D. Here, INS is linked to type 2 diabetes mellitus.