INS and type 2 diabetes mellitus: Within the first novel T2D-associated locus in chromosome 1q41 (LYPLAL1-ZC3H11B, rs2820443, OR = 1.07 [1.04–1.09], p = 2.6 × 10−8), several variants have been previously associated with waist-to-hip ratio, height, visceral adipose fat in females, adiponectin levels, fasting insulin, and non-alcoholic fatty liver disease18–23.