Especially, inhibition of LRIG2-induced cell death by ectopic expression of MCL-1 or by depletion of either BAK or BAX (Fig. 2d, e) further support our conclusion that LRIG2 induces apoptosis in Hec-1A endometrial carcinoma cells by regulating the delicate equilibrium among the BCL-2 family of proteins. Here, BAX is linked to endometrial carcinoma.