LRIG2 and central nervous system cancer: In glioblastoma, however, LRIG2 reportedly exerts oncogenic effects; LRIG2 knockdown increases apoptosis and decreases proliferation; LRIG2 overexpression stimulates growth of xenotransplanted gliomas; and mice expressing truncated LRIG2 are less prone to develop gliomas induced by platelet-derived growth factor subunit B30–32.