Ectopic expression of LRIG2 downregulated the pro-survival BCL-2 family members, including MCL-1, BCL-xL, BCL2A1, and BCL-2, whereas the pro-apoptotic BCL-2 family members, such as BAK, BAX, and BAD, were upregulated by LRIG2 in endometrial cancer cells (Fig. 2a). This evidence concerns the gene BCL2 and endometrial cancer.