Besides the Warburg effect, tumour cells also undergo lipid remodelling mostly characterised by aberrant de novo lipogenesis, cholesterogenesis due to oncogenic-driven lipogenic enzyme overexpression (e.g., fatty-acid synthase (FASN), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)). The gene discussed is HMGCR; the disease is neoplasm.