Analysis of the HIF2α gene (EPAS1) and the protein expression profile in CRC cell lines showed that HT29 cells, despite a high-LD content, do not express high HIF2α protein levels, which could be related to the high degree of post-translational modifications of this transcription factor23 (Supplementary Fig. 9a and b). The gene discussed is EPAS1; the disease is colorectal carcinoma.