We first explored the expression profile of perilipins in CRC cell lines and showed that PLIN2 was the major perilipin present in SW620 cells, whereas HT29 cells expressed more PLIN3, 4 and 5; however, no PLIN1 protein expression was detected in all cell lines (Supplementary Fig. 12a and b). This evidence concerns the gene PLIN3 and colorectal carcinoma.