TNFSF13B and systemic lupus erythematosus: On the other hand, impaired antibody responses to T cell-independent antigens41,43 as well as decreased plasma cell generation47, a consequence of blunted response to cytokines BAFF and APRIL45 in TACI knock-out C57BL/6 mice, would predict attenuated SLE manifestations in TACI deficient lupus mice.